Whether you need to take cephalosporin for anal fissure needs to be determined according to the specific situation, if infection occurs it is possible to take it, and it is recommended to do so under the guidance of a doctor. Anal fissure is in the anus below the dentate line, due to the anal canal skin fissure after the formation of small ulcers, often shuttle-shaped, generally parallel to the longitudinal axis of the anal canal, in addition to often cause severe pain. Because of the proximity of the anus, so the anal fissure is more prone to infection, then you can take antibiotics under the guidance of the doctor, such as cephalosporins, penicillin and so on. In addition, you can also use warm water sitz bath therapy, for more serious anal fissure, it is recommended to carry out surgical treatment. Usually pay attention to light diet, while maintaining the local hygiene of anal fissure, keep the local dry, clean. Drugs need to follow the doctor’s instructions reasonable application.