It is abnormal for a patient to have a higher body temperature at night than during the day. Clinically, it is a nocturnal fever and early coolness, which is pathological and requires relevant investigations and treatment, commonly blood tests, biochemical routine tests, chest CT, etc. Patients with high nighttime temperatures during an epidemic indicate the possibility of novel coronavirus infection and should have their temperature measured and undergo relevant isolation as early as possible. This includes home isolation below 38°C, and above 38°C should go to the fever clinic of the nearest hospital for diagnosis and treatment. Nucleic acid testing and chest CT testing can be used to determine if the infection is a novel coronavirus. After clinical clarification, symptomatic treatment can be given by sputum fever clear injection, Xiyampin injection, interferon, ribavirin, etc., and appropriate application of ventilator for supportive treatment.