The steps for waking up a severely comatose patient mainly include: 1. Stabilizing the patient’s vital signs, mainly to keep the airway open and the circulation stable. Keeping the airway open mainly includes tracheal intubation and ventilator-assisted ventilation. Circulatory stability is mainly through central venous pressure monitoring, rehydration, blood pressure monitoring, etc. 2, need to actively deal with the original disease, if it is due to trauma leading to shock, need to actively deal with trauma. If the patient is in coma due to cerebral hemorrhage, the patient needs to control the symptoms of increased intracranial pressure due to hemorrhage through surgery or drug treatment.3. After the patient’s condition is stabilized, the patient needs to be actively rehabilitated to promote wakefulness, but for some patients with more serious injuries, they may not wake up through the above steps, which is mainly due to the damage of the primary disease is too heavy.