How long entecavir should be taken clinically depends on how far the disease has progressed before taking the drug and what effects have occurred after taking the drug. If you have cirrhosis before taking the drug, whether it is compensated or decompensated, entecavir should be taken for life. If you do not have cirrhosis before taking the drug, and you are a patient with hepatitis B major triplet, you should take entecavir for at least 3 years, and you should also achieve the conversion of major triplet to minor triplet, and the conversion of DNA to negative for at least 3 years, before you can consider stopping entecavir. If you were a minor triple-positive patient before taking the drug, you should take the drug for at least 3 years, and you should achieve the conversion of hepatitis B surface antigen for at least 3 years, and you can stop entecavir only if you achieve these two conditions at the same time.