Quadruple therapy is recommended for H. pylori. Triple therapy is generally effective in treating H. pylori, and quadruple therapy is now commonly used. Triple therapy refers to an acid suppressant and two antibiotics, due to the current high rate of antibiotic resistance, quadruple therapy is more effective in eradicating H. pylori, specifically an acid suppressant, a bismuth agent, plus two antibiotics. Acid suppressants are proton pump inhibitors, such as rabeprazole, omeprazole, pantoprazole, and esomeprazole. Among the commonly used antibiotics, amoxicillin has low resistance, few side effects, and high sterilization rate. If the patient is not allergic to penicillin, one of the two antibiotics includes amoxicillin, and the other antibiotic can be clarithromycin, furazolidone, tetracycline, metronidazole, and levofloxacin. Of these, metronidazole and levofloxacin have high rates of resistance and are rarely used. Bismuth agents are usually bismuth potassium citrate and colloidal bismuth pectin. A course of treatment lasts about 14 days. The breath test is repeated one month after stopping the medication to find out the eradication of H. pylori. H. pylori should be checked in time and treated under the guidance of a doctor.