The full name of hyperthyroidism is hyperthyroidism, and the swelling that occurs in patients with hyperthyroidism who take medication may be the result of hyperthyroidism manifesting itself as pretibial mucous edema. It is also possible that the medication dose is too high and hypothyroidism occurs, causing mucous edema. Hyperthyroidism causes an excess of thyroid hormones in the blood circulation, which leads to increased excitability of the nervous and circulatory systems and hypermetabolism; anti-thyroid drugs such as methimazole, propylthiouracil and radioactive iodine can usually be prescribed as treatment. Puffiness after taking medication for hyperthyroidism may be due to the fact that a few patients with hyperthyroidism may develop diffuse toxic goiter skin lesions, which cause accumulation of mucopolysaccharides in the extracellular matrix or destruction of muscle fibers and lamellar infiltration of lymphocytes, resulting in diffuse toxic goiter skin lesions, which usually appear as puffiness on the dorsum of the feet. In the process of treating hyperthyroidism, overdose of medication may result in hypothyroidism, which may manifest as mucous edema and a fat round face. When the above symptoms appear, it is recommended to go to the hospital in time, under the guidance of the doctor for standardized treatment.