There is no such thing as what medication is the most feared for Raynaud’s disease. Commonly used medications for Raynaud’s disease include calcium channel blockers and peripheral vasodilators. Drug treatment is not effective, but also through plasma replacement, sympathectomy and other methods of treatment. 1. Calcium channel blockers: these drugs can diastole blood vessels, increase coronary blood flow, so as to Raynaud’s disease triggered by the end of the finger cold, numbness, color white cyanosis and other symptoms, has a very good effect on the improvement. Commonly used drugs are nifedipine, amlodipine and so on. Need to pay attention to low blood pressure, headache, nausea and other side effects, and serious heart failure and low blood pressure can not use this drug. 2. Peripheral vasodilator: it can directly dilate the smooth muscle of small blood vessels, preventing the long-term ischemia of the finger end of the finger belly flattening, necrosis and other symptoms. Commonly used drugs are niacin, prazosin and so on. Niacin may cause itching and skin flushing. It is contraindicated in gout and diabetes. Prazosin may cause side effects such as fatigue and headache. If the medication does not work well and there is already a trophic disorder of the skin tissue, sympathectomy may be used to relieve the condition. Plasma exchange may also be performed at the discretion of those with exceptionally severe symptoms. Specific medication and treatment plan should be determined by a doctor’s guidance, and treatment should be in accordance with the doctor’s instructions.