Although some adverse reactions may occur with the rabies vaccine, the incidence of these adverse reactions is very low. Also, among the adverse reactions to rabies vaccine, there is no damage to the brain. The corresponding adverse reactions may be the appearance of local reactions at the injection site, such as pain, redness, or itching. It is possible to develop hard nodules, but their occurrence is rare. Adverse reactions that can be seen throughout the body include fever, but it is generally low, and symptoms such as weakness and headache. Nausea, vomiting, joint and muscle aches and pains may also occur, but one are unmanageable. Rare adverse reactions are more pronounced fever, or an allergic rash. The rarest adverse reactions are usually more serious, such as anaphylaxis, which does not include damage to the brain. Only after the rabies virus has traveled up into the central nervous system can it cause damage to the brain.