Red, swollen and hard pimples may be associated with papular acne and skin boils, which are treated with targeted anti-inflammatory drugs and, if necessary, combined with drugs that have the effect of dissolving keratin. 1. Papular acne: a more common type of acne, as a chronic inflammatory skin disease, the treatment is mainly anti-inflammatory, including oral anti-inflammatory drugs and topical anti-inflammatory drugs. (1) Oral anti-inflammatory drugs: commonly used oral anti-inflammatory drugs include doxycycline hydrochloride tablets, metronidazole tablets and clindamycin capsules. (2) Topical anti-inflammatory drugs: topical erythromycin isotretinoin gel can also be used topically with both anti-inflammatory and keratolytic effects of the drug. 2. Skin boils: an acute infectious skin disease, the lesions are mainly located around the deep part of the hair follicles, in the treatment of the main oral and topical anti-inflammatory way, such as oral roxithromycin capsule, topical erythromycin ointment, mupirocin ointment and so on. Due to the individual differences in treatment effects, the use of the above drugs should follow the doctor’s instructions. It is recommended that the patient go to the hospital in time, after clarifying the cause of the disease, under the guidance of the doctor to standardize the treatment.