Reticular cyanosis is a skin spasmosis, a skin manifestation of certain diseases, and some normal people also develop reticular cyanosis in cold environments. Gangrene is a specific morphologic change of black and dark green color due to secondary infection by spoilage bacteria and other factors after tissue necrosis. Both are seen together in the skin lesions of polyarteritis nodosa. Polyarteritis nodosa, also known as periarteritis nodosa and necrotizing arteritis, polyarteritis, etc., is a fatal disease. The clinical course of the disease is rapid and extensive, usually involving the systemic arterial system. The clinical manifestations are complex and varied, depending on the site or organ involved. How can we prevent this condition from occurring? Polyarteritis nodosa, a connective tissue disease of unknown origin that affects multiple organs and systems, has a variety of clinical manifestations, characterized by skin nodules arranged along superficial arteries or irregularly clustered near blood vessels, with pain and pressure, and a rosy, bright red or near-normal skin color, which can be fatal or disabling in severe cases. Therefore, patients with the above-mentioned symptoms and signs must be hospitalized in a hospital with good conditions to make a clear diagnosis, be given systematic treatment, and adhere to medication and regular follow-up as prescribed by the doctor. At the same time, do not abuse drugs and prevent drug and food allergy and infection, especially hepatitis B virus infection. 1, general treatment (1) hospitalization: nodular polyarteritis in a period of time requires hospitalization. If there is heart failure, coronary hypoxia ischemia or infarction, arrhythmia, pericarditis are required to stay in the ward until the condition is stable. (2) Surgical treatment: Nodular polyarteritis occasionally requires emergency surgery, especially for gastrointestinal bleeding, perforation, and retroperitoneal bleeding. The preoperative treatment affects the surgical outcome with blood volume replenishment, heart failure, and control of cardiac rhythm disturbances. Those with indications can be arteriographed before surgery, and hormones are applied on the day of surgery or 3 days after surgery to compensate for the emergency at the time of surgery, usually 100 mg of hydrocortisone is applied every 6 hours. (3) Other: such as physical and psycho-psychiatric therapy, etc. 2.Medication Hormone can control polyarteritis nodosa. Start with hormone according to the extent of the lesion to determine its dosage, delivery mode and route. In critical cases, intravenous infusion of hydroxylated hormones (such as hydrocortisone, etc.) can be used daily in 4 applications equivalent to prednisolone 60mg. After improvement, the dosage is gradually reduced by oral administration and changed to every other day. Be aware of its side effects. Acidulators may relieve GI symptoms. Side effects can be avoided or alleviated by the shock method with 1g of methylprednisolone. However, attention should be paid to the transient side effects of this Council. Cytotoxic agents are beneficial for this disease. Commonly used are cyclophosphamide and azathioprine. Aspirin can be used in polyarteritis nodosa. Combined treatment of polyarteritis nodosa is significantly better than the treatment group alone. 3, Chinese medicine diagnosis and treatment Damp-heat stasis type nodular polyarteritis, manifested as the onset of rapid, subcutaneous nodules, slightly higher than the skin surface, burning red swelling, accompanied by headache, sore throat, arthralgia, increased body temperature, thirst, dry stool, yellow urine, can be used to add reduction of the four miao Yongan Tang (Angelica 10 grams, Xuan Shen 15 grams, Sheng Di 30 grams, Yin Hua 15 grams, Chuan Xiong 9 grams, red flower 9 grams, Tu Fu Ling 15 grams); cold damp into the ligament. The manifestation is dark red skin lesions, repeatedly lingering, accompanied by joint pain, aggravated by cold, cold limbs, no thirst, soft stools, can be used with Angelica Sinensis Sibi Tang Plus Reduction (Angelica Sinensis 15g, Hossein 3g, Moutong 6g, Gui Zhi 10g, White Peony 10g, Red Peony 10g, Chicken Blood Vine 15g).