Total IgE greater than 1000IU/ml is serious and needs to be taken seriously should go to the hospital immediately for diagnosis and treatment. IgE, or immunoglobulin E, is an antibody that mediates type I allergic reactions and is associated with allergic reactions, parasitic infections and skin allergies. The normal serum level of this antibody in adults ranges from 20 to 200 IU/ml, but it is generally considered to be abnormally high when it is greater than 333 IU/ml (800 ng/ml), and should be combined with other symptoms to confirm the diagnosis and treatment. If there are symptoms such as itching, redness, swelling and eczema, it may be an allergic reaction. Anti-allergic drugs such as loratadine and cetirizine hydrochloride tablets can be used. If there are no allergic symptoms, it may be a parasitic infection, which can be treated with anthelmintic drugs such as albendazole or mebendazole. It can also be seen in eosinophilia, liver disease, and heavy chain disease. The use of the above drugs must be taken under the supervision of a doctor. If Ige is higher than 1000IU/ml, you should go to the hospital immediately to seek professional diagnosis and treatment to avoid delay.