The difference between Langerhans’ cell hyperplasia and leukemia in children is mainly in the symptoms and pathological manifestations. 1. Symptoms: Langerhans cell symptoms are mainly generalized bone damage, such as skull, ribs, pelvis, scapula and other parts of the deformity, and there will be convex eyes, optic neuritis and other symptoms. The symptoms of leukemia patients are mainly infection, bleeding, fever and other systemic symptoms. 2. Pathological manifestations: The pathological manifestations of Langerhans cells are mainly the massive proliferation of Langerhans cells to form eosinophilic granulomas, and the destruction of bone quality. The main pathological manifestations of leukemia are the proliferation of leukemia cells, the increase of primitive cells in bone marrow, and the relative decrease of other non-leukemia cells.