Hepatitis B is currently difficult to treat and can easily develop into cirrhosis. With scientific progress and the popularization of health knowledge, the prevention and treatment of hepatitis B in the future will certainly make a breakthrough. 1, prevention; since the eighties China’s large-scale hepatitis B vaccination, hepatitis B virus infection gradually reduced, with the passage of time China’s chronic hepatitis B virus infection will gradually reduce, the future will be close to the developed countries level of about one to three percent. 2, treatment; with the depth of scientific research, the DNA vaccine, chronic hepatitis B virus infection will be cured. Stem cell therapy for chronic hepatitis B will be a great success. In short, a breakthrough in the treatment of chronic hepatitis B will definitely be achieved.