The normal standard of pepsinogen ratio is greater than or equal to 7.5, which is an indicator for diagnosing the risk of cancer, with sensitivity and specificity around 80%, and it is one of the important tests for early screening of gastric cancer. 1. The metabolic process of pepsinogen has pepsinogen Ⅰ and pepsinogen Ⅱ, and the ratio of pepsinogen Ⅰ to pepsinogen Ⅱ of healthy people is greater than or equal to 7.5. 2. If the ratio is 3.0~7.5, there may be gastric mucosal damage or H. pylori infection. 3. A ratio of less than 3.0 suggests significant damage to the gastric glands, such as atrophic gastritis, intestinal epithelial hyperplasia, and gastric cancer. It is recommended that patients with abnormal pepsinogen ratio should go to regular hospitals for timely consultation and standardized treatment under the guidance of doctors, so as to avoid delaying the condition or causing adverse reactions.