Sleepless body fatigue may be sleep disorder, hypothyroidism, anemia and other diseases. 1. Sleep disorders: patients often feel that the quality of sleep is poor, although the sleep time is more adequate, but still rest is not good, feel always sleepy, body fatigue. 2. Hypothyroidism: thyroid hormone is one of the most important hormones to maintain the normal function of the nervous system and the normal excitability of neurons, and the lack of thyroid hormone affects the body’s functions, resulting in sleeplessness and fatigue. 3. Anemia: anemia patients due to insufficient hemoglobin, blood red blood cell oxygen carrying capacity is reduced, resulting in insufficient oxygen supply to the body’s vital organs. It will cause the corresponding dysfunction. When the blood supply to the organs is insufficient, it will produce symptoms such as sleeplessness and body fatigue. It is recommended that patients should go to the general practice of regular hospitals in a timely manner to clarify the cause of the disease and take targeted treatment under the guidance of professional doctors.