Urticaria, commonly known as “rubella”, is a limited edema of the skin and mucous membranes that occurs due to a temporary increase in vascular permeability, i.e., hives. Cephalosporin and loratadine should not be taken together when you have hives. Urticaria is due to allergens into the body, resulting in the occurrence of a kind of allergic reaction of small blood vessels under the skin mucous membrane, in the treatment of the main is to remove the sensitizer, and at the same time, symptomatic administration of some anti-allergic and anti-itching medicines, such as loratadine tablets, cetirizine and so on. Cephalosporin is a commonly used anti-inflammatory drug, which is only suitable for the treatment of infectious diseases caused by sensitive bacteria, and has no therapeutic effect on urticaria. The use of cephalosporin in the absence of indications for its use can lead to drug resistance and also increase the adverse effects of the drug. Urticaria should be timely medical treatment, under the guidance of the doctor for standardized treatment, do not unauthorized use of drugs.