There is no clear regulation on when to take hydrochlorothiazide, it is usually recommended to take it in the morning, it is recommended to fix the medicine at the same time every day, and it should be used in accordance with the doctor’s instructions. Hydrochlorothiazide is a diuretic, which can inhibit water and sodium reabsorption and increase the excretion of ions such as sodium, potassium, chlorine, phosphorus and magnesium, and it can be used to treat edematous diseases such as congestive heart failure, cirrhotic ascites, as well as to treat hypertension and uremic syndrome. Hydrochlorothiazide does not specify what time is good to take, but because of its diuretic effect, if taken at night, increased nocturia may affect the patient’s quality of sleep. Hydrochlorothiazide should not be used in lactating women. Its use may cause hydroelectrolyte disorders such as hypokalemia, hypochloremic alkalosis, hyponatremia, dehydration, as well as hyperuricemia, hyperglycemia, and allergic reactions. Hydrochlorothiazide should be used under medical supervision.