Intravenous medication is usually the treatment of choice for pyelonephritis, and only very mild pyelonephritis can be treated with oral antibiotics. Cephalosporin or quinolone antibiotics such as cefixime and levofloxacin are usually chosen. Pyelonephritis is categorized into acute pyelonephritis and chronic pyelonephritis. Acute pyelonephritis and acute attacks of chronic pyelonephritis are usually caused by bacterial infections, in which case the patient usually needs to apply antibiotics intravenously, and oral medication is not an option. Only very mild pyelonephritis is treated with oral antibiotics, usually cephalosporins such as cefixime or quinolones such as levofloxacin are used empirically, and the use of antibiotics is adjusted according to the results of urine culture sensitization at a later stage. If chronic pyelonephritis non-acute exacerbation, the therapeutic drugs need to be determined according to the patient’s condition, those with hypertension choose antihypertensive drugs (such as valsartan, nifedipine extended-release tablets), patients with renal anemia can choose roxarestat and other drugs for oral treatment. All of the above medications should be under the guidance of a physician, and should not be self-selected medication to avoid aggravating the condition. It is recommended that patients with pyelonephritis go to regular hospitals as soon as possible for comprehensive treatment under the guidance of specialists.