High blood pressure in the middle of the night can be self-adjustment, take medication, and when the symptoms are serious, you should urgently consult a doctor or call an ambulance. 1. Self-adjustment: control blood pressure should pay attention to the control of sodium intake in life, balanced diet, eat more fresh fruits and vegetables, appropriate aerobic exercise, to avoid too much emotional fluctuations, anxiety, tension, etc., to ensure that the optimistic mood. 2. Taking medication: Suffering from high blood pressure should regularly take antihypertensive drugs. Commonly used antihypertensive drugs are chlorosartan hydrochlorothiazide, sotalol, nifedipine, lacidipine, metoprolol, etc.. If the blood pressure is not well controlled, you should consider increasing the dosage of the drugs appropriately or combining the drugs. 3. Prompt medical consultation: If the blood pressure is suddenly increased in the middle of the night, you can take captopril, nifedipine to lower the blood pressure urgently, if there is serious chest tightness, chest pain, dyspnea, you should consult a doctor or call 120 emergency. Drugs should be used under the guidance of a physician.