Dolutegravir is more effective when combined with lamivudine. The combination of the two is a blocking drug that can be used to block HIV. 1. Dolutegravir: It can be used in combination with other antiretroviral drugs to treat human immunodeficiency virus infection, and it is important to note that it must be taken by people who are 12 years of age or older. The common adverse effects of dolutegravir include rash, fever, joint pain, facial edema, angioedema and conjunctivitis, etc. It is necessary to pay attention to the prohibition of combining with drugs such as dolutegravir, and during the treatment period, it is necessary to pay attention to whether it causes hypersensitivity reactions. 2. Lamivudine: a nucleoside reverse transcriptase inhibitor, with anti-HIV effects, the more common adverse reactions include headache, nausea, vomiting, diarrhea, abdominal discomfort and respiratory tract infections. Lamivudine is contraindicated in people who are allergic to it, and care needs to be taken to receive regular monitoring during treatment. Dotiravir is an HIV integrase inhibitor, which can prevent the HIV virus from entering the cells, and can be used in combination with lamivudine retroviral drugs for the treatment of human immunodeficiency virus (HIV), which has a synergistic effect and is more effective. In addition, the application of all of the above medications carries certain risks, and patients need to be guided by a specialist.