Nine-valent usually refers to the nine-valent human papillomavirus vaccine (HPV vaccine), nine-valent 2nd shot missed the time, depending on the time delay, if it exceeds the time too long, it will affect the effectiveness of the vaccine. Nine-valent HPV vaccine is suitable for the preventive vaccination of women aged 16-26 years old for the prevention of cervical cancer, precancerous lesions or atypical lesions caused by HPV virus in the following diseases. The HPV vaccine is generally recommended to be given at months 0, 2 and 6. According to the clinical research data, it is recommended that the interval between the second dose and the first dose should be at least 1 month, while the interval between the third dose and the second dose should be at least 3 months, and all 3 doses should be completed within one year. Therefore, it is not a big problem to delay the vaccination for a certain period of time, but it is recommended to receive the vaccination as soon as possible, preferably within one year. Each vaccinated woman has a different physical condition and her reaction to the vaccine is different, so it is recommended to follow the prescribed schedule when receiving the vaccination and try to avoid delaying the vaccination.