If syphilis is detected early and treated early and regularly, it usually does not affect life expectancy; if it is detected late and the syphilis condition is serious, it will have an impact on life expectancy. Syphilis is a sexually transmitted disease (STD) caused by infection with the syphilis spirochete. According to the course of the disease, syphilis can be divided into early syphilis and late syphilis. Early syphilis is mainly manifested as hard chancre, syphilis rash, flat warts, etc.; late syphilis is mainly manifested as syphilitic dendritis, cardiovascular syphilis, etc., which can result in serious damage to organs of multiple systems. Syphilis can’t be cured by itself, it should be treated in time, the earlier the treatment time, the greater the impact on the prognosis. If syphilis is detected early, regular anti-syphilis treatment is carried out early, and regular review is conducted, it generally does not affect life expectancy; if it is detected late, and the symptoms of syphilis are severe, causing irreversible damage to internal organs and their functions, it may cause death, thus affecting life expectancy. It is recommended that patients with syphilis go to regular hospitals in time, and under the guidance of doctors to carry out regular anti-plasmodium treatment, and not to use their own medication, which may cause serious adverse reactions, and even affect life expectancy.