The most common causes of endometrial thinning are endocrine disorders, infections and uterine operations. Endocrine disorders include low oestrogen levels, ovulation disorders and growth hormone deficiency; acute or chronic uterine infections can lead to destruction of the basal lining of the endometrium, including bacterial infections, reproductive tuberculosis, mycoplasma infections and chlamydia infections.
Clinical operations that affect the endometrium include curettage, hysteroscopic myomectomy, removal of endometrial polyps and laparoscopic myomectomy through the uterine cavity, all of which may damage the endometrium and lead to endometrial thinning and cavity adhesions.