Formal hypoglycemic drugs, such as insulin and its analogs, alpha-glucosidase inhibitors, etc., are generally safe and effective, and there is no such thing as a hypoglycemic drug that minimizes liver and kidney damage. However, if the liver and kidneys are not functioning properly or the dosage exceeds the safe range, it will increase the burden on the liver and kidneys, affect liver and kidney function, and affect the stability of glucose-lowering drugs and increase the risk of side effects. Oral hypoglycemic drugs, such as α-glucosidase inhibitors, are generally metabolized in the liver and excreted through the kidneys. If the patient’s liver and kidney functions are normal, normal metabolism and excretion through the liver and kidney will not affect the liver and kidney functions. When the liver and kidney function are abnormal, using oral hypoglycemic drugs at the original dose will aggravate the burden on the liver and kidneys, and at the same time affect the stability of glucose lowering. Since glucose-lowering drugs often need to be taken for a long period of time, it is necessary to check your liver and kidney function before choosing them. Due to the degenerative changes in the body of the elderly, the liver and kidney functions are relatively weak and should be more concerned about the liver and kidney functions. Liver and kidney function should be rechecked three to six months after taking the drug, and the drug treatment should be adjusted in time if there is any problem. Due to individual differences, there is no absolutely safe hypoglycemic drugs, it is recommended to follow the doctor’s advice to choose the most suitable hypoglycemic drugs. After the occurrence of adverse reactions, timely consultation, allergic to the drug is prohibited.