Multiple retroperitoneal lymph nodes may be caused by infections of intra-abdominal organs, such as pancreatitis, chronic colitis, peritonitis, abdominal lymphatic tuberculosis, etc., or by lymphatic metastases of malignant tumors or lymphoma. It can also be caused by lymphatic metastasis of malignant tumors or lymphoma, etc. It should be diagnosed clearly and treated accordingly as prescribed by doctors. 1. Inflammatory infections: mostly seen in peritonitis, pancreatitis, nephritis, hepatitis, biliary tract infection, chronic colitis and other abdominal infections. Patients often have abdominal pain, abdominal distension, diarrhea and other manifestations, and even fever, hypotension, fainting and other manifestations of infectious shock. After the diagnosis is clear, surgery, anti-infection and anti-shock treatment should be given according to the doctor’s instructions. Anti-infective treatment usually requires the use of third-generation cephalosporins such as cefoperazone, ceftriaxone sodium and so on. Abdominal lymphatic tuberculosis can also lead to multiple enlargement of abdominal lymph nodes, which can be treated with isoniazid, rifampicin, ethambutol and other drugs after diagnosis. 2. Malignant tumors: when patients suffer from malignant tumors such as colon cancer, rectal cancer, kidney cancer, pancreatic cancer, liver cancer, stomach cancer, etc., all of them can lead to retroperitoneal lymph node enlargement through lymphatic metastasis. Lymphoma and lymphoblastic leukemia can invade retroperitoneal lymph nodes, resulting in multiple lymph node enlargement. When patients have multiple retroperitoneal lymph nodes, they should consult a doctor in time, complete the examination, make a clear diagnosis and follow the doctor’s instructions for treatment.