ST-T change is a term used in electrocardiography and does not directly indicate whether a patient’s condition is serious or not; the cause of the condition needs to be clarified before evaluation. ST-T change is a commonly used term in ECG examination, which suggests that the patient’s cardiomyocytes have shown abnormal electrical activity in the process of completing repolarization. This kind of abnormal performance is mostly related to myocardial ischemia. Generally speaking, the more obvious the ST-T change is, the more severe the myocardial ischemia may be, but this does not indicate the severity of the patient’s condition, and it is necessary to clarify the etiology leading to the appearance of the ST-T change, and evaluate the severity of the patient’s disease according to the etiology. If the patient is in a state of emotional excitement, tension, anxiety and depression, or ST-T changes after strenuous exercise, this is a normal physiological phenomenon, appropriate adjustment can be restored to normal, this situation is not serious; coronary atherosclerotic heart disease, dilated cardiomyopathy and other ST-T changes caused by this situation is relatively serious, should be treated in a timely manner. Therefore, when ST-T changes appear in ECG, you should consult a doctor in time, clarify the cause of the disease as soon as possible, and carry out standardized treatment under the guidance of a professional physician, which can improve the prognosis.