It is not possible to determine which diuretic antihypertensive drug has the least side effects; the side effects of a drug are related to the response to the drug. There are several varieties of diuretics used clinically to lower blood pressure, such as indapamide, furosemide and spironolactone. Most of the adverse effects of diuretics are electrolyte disorders, and diuresis can lead to the loss of a variety of effective substances, but different patients have different responses to the drugs, so the side effects of the drugs can be significantly different. Diuretics are the basic medication used in the treatment of hypertensive patients, which can reduce the blood volume in the body and thus play a role in reducing pressure. Different diuretics have different mechanisms of action, the intensity of diuresis will also be different, different patients will have different responses to the effect of the drug, so for the adverse effects of the drug can not make a direct comparison. In the process of taking diuretics to reduce blood pressure, there is regular review of electrolytes to prevent serious electrolyte disorders.