Shoulder pain after taking Anrotinib may be caused by drug side effects, trauma, cervical spondylosis, etc. It can be treated by general treatment, medication and surgery. 1. Drug side effects: Anrotinib hydrochloride is a kind of targeted drug, which may cause patients to have the adverse reaction of shoulder pain after taking it. It can be treated with topical diclofenac sodium ointment for pain relief. If the pain is severe, patients can take ibuprofen and other medications for pain relief under the guidance of a doctor, and adjust the medication regimen if necessary. 2. Trauma: Shoulder pain can be caused by squeezing or collision, which can be relieved by cold compresses in the early stage and hot compresses in the later stage. If the patient has serious soft tissue damage or fracture, surgery is needed. 3. Cervical spondylosis: cervical spondylosis can also cause arm pain, the patient should avoid prolonged exposure to the desk, through the way of hot compresses to promote blood circulation, you can use methylcobalamin, ibuprofen and other drugs under the guidance of the doctor for treatment. After taking Anrotinib physical discomfort, may also be other reasons, please timely medical treatment, active diagnosis and treatment, in order to avoid adverse consequences.