Symptoms of adult total pituitary hypopituitarism are related to factors such as the type of pituitary hormone deficiency, e.g., insufficient secretion of luteinizing hormone and follicle stimulating hormone, which in female patients may be characterized by amenorrhea, breast atrophy, loss or loss of libido, decrease in vaginal secretion, pain during sexual intercourse, infertility, loss of pubic and axillary hair, and atrophy of the uterus and vagina. Consultation with a doctor is recommended. 1. Insufficient secretion of gonadotropins (1) Symptoms of gonadotropin insufficiency in men: scanty pubic hair, increased subcutaneous fat, underdeveloped muscles, atrophy of testicles, and loss of libido; (2) Symptoms of insufficient secretion in women: amenorrhea, loss of pubic hair, atrophy of breasts, and loss of libido; 2. Insufficient secretion of thyroid-stimulating hormone (1) In less severe cases, symptoms such as fear of cold, lack of appetite, constipation, and indifference may occur; (2) In more severe cases, symptoms such as mucous edema, chills, mental retardation or psychosis may occur; (3) Growth hormone deficiency: adults show a decrease in muscle strength, poor physical strength, obesity, attention or memory loss, etc.; and It can be seen that the symptoms of total pituitary hypopituitarism in adults have a variety of manifestations, depending on the type of hormone that is deficient in the pituitary gland after the lesion and other related factors. It is recommended that patients with total pituitary hypopituitarism seek medical attention in a timely manner.