Patients with systemic sclerosis can eat sea cucumber in moderation when their kidney function is normal to supplement protein and other nutrients for the human body; however, patients who are allergic to seafood should not eat sea cucumber; and when renal insufficiency occurs in the later stage, they need to follow the doctor’s advice to limit the intake of sea cucumber. Systemic sclerosis is a connective tissue disease, and its pathogenesis may be related to genetics, immunity, infection, chemical substances and other factors, and diet has little to do with it. Patients with systemic sclerosis are mainly characterized by symmetrical skin sclerosis, which can be divided into swelling, sclerosis and atrophy phases according to the course of the disease, with different skin changes in different periods. In the atrophic stage, the lesions can progress to the subcutaneous tissues, muscles, etc., and the skin directly adheres to the bone surface as “periosteal-like” changes. Sea cucumber belongs to invertebrates, echinoderms and sea cucumbers. Sea cucumber is rich in protein, amino acids, vitamins and other nutrients. Each 100 grams of sea cucumber contains 78 calories, 2.5 grams of carbohydrates, 16.5 grams of proteins, 0.2 grams of fats, 51 milligrams of cholesterol, 285 milligrams of calcium and 13.2 milligrams of iron. Moderate consumption of sea cucumber by patients with systemic sclerosis can replenish body protein and other nutrients, which is beneficial to human health. When renal insufficiency occurs in later stages, it is necessary to limit the intake of sea cucumber to avoid aggravating the burden on the kidneys. However, patients who are allergic to seafood should avoid consuming it to avoid inducing allergic reactions.