A famous formula created by Zhang Zhongjing to treat liver depression and spleen deficiency is Free San. Created by the famous Chinese medicine practitioner Zhang Zhongjing, Easy San is a conciliatory formula that consists of licorice, angelica, poria, white peony, atractylodes macrocephala, and chaihu. It has the efficacy of harmonizing the liver and spleen, dispersing the liver and relieving depression (treating depression by dispersing liver qi), nourishing blood and strengthening the spleen. Clinically, this formula is mainly used in treating the symptoms of liver depression and blood deficiency (liver qi stagnation and blood deficiency) and spleen weakness, such as pain in both dregs, headache and dizziness, dry mouth and throat, fatigue (lack of mental energy), poor appetite, or irregular menstruation, and stringy and weak pulse. Its adverse reactions and contraindications are not clear. This drug should be used under the guidance of a professional Chinese medicine practitioner to identify the symptoms, and should not be used blindly on its own to avoid adverse effects.