Pain on pressure in the hepatic region is not normal, and this is a positive sign on clinical examination. However, there are many clinical causes of pain on pressure in the liver area, most likely caused by diseases of the hepatobiliary system or by diseases other than the hepatobiliary system. Diseases of the hepatobiliary system are mainly seen in liver abscess, liver cyst infection, giant hepatic hemangioma, acute and chronic hepatitis, liver cirrhosis, cholecystitis, cholangitis, primary liver cancer, metastatic liver cancer, etc. Rib chondritis, intercostal neuralgia, rib fractures, and subdiaphragmatic abscesses can also cause pain on pressure in the liver region. Therefore, when clinical pain on pressure in the liver area occurs, it is also necessary to further determine the specific cause in combination with symptoms and relevant auxiliary examinations. Some causes of pain on pressure in the liver area can be treated conservatively, such as acute and chronic hepatitis and costochondritis. Some causes of pain also require surgical treatment, such as primary liver cancer and subphrenic abscess.