Joint melanin deposits can be alleviated by lifestyle changes such as regular exfoliation, or removed with topical medications such as Vitamin A cream. 1. Lifestyle changes: Joint melanin deposits are usually caused by local friction and lack of attention to cleanliness. Normally, you can exfoliate regularly to accelerate the shedding of aging cells, which can reduce pigmentation. In addition, attention should be paid to reduce local friction, pay attention to sunscreen. 2. Topical medication: Melanin deposition can be removed by topical medication such as vitamin A cream, or apply urea cream, vitamin E cream and other relief. Generally speaking, localized melanin deposits in the joints will not affect the health of the body, if you need to use the above drugs, should be used under the guidance of a physician.