Esophagitis is an inflammatory condition that occurs when the esophageal mucosa is irritated by various factors that damage the esophageal mucosa, with different causes and different treatments. The most common form of esophagitis is caused by gastroesophageal reflux. Under normal circumstances, stomach acid does not reflux into the esophagus. If the pancreatic orifice, which prevents acid reflux into the tube, becomes loose and the pressure in the stomach is relatively higher than the pressure in the esophagus, stomach acid, bile and other for contents will reflux into the esophagus. Long and frequent reflux can damage the esophageal mucosa and cause esophagitis. Bad habits such as excessive abdominal girth, lying flat after meals, overeating, sweet or greasy foods, smoking and drinking alcohol, and eating too much can cause reflux from the stomach into the esophagus. Pharmacological treatment of esophagitis includes several aspects: Proton pump inhibitors are also commonly used clinically to inhibit gastric acid secretion, commonly used are omeprazole, condomatolazol, rabeprazole, lansoprazole, estramiprazole, etc. H2 receptor blockers can reduce gastric acid secretion, and their effect is weaker than that of proton pump inhibitors, which can be used for symptomatic treatment or maintenance period as needed. Commonly used are cimetidine, ranitidine and famotidine. Gastroesophageal reflux is a dysmotic disease, when the first two drugs are ineffective, can be combined with the application of prokinetic drugs. The commonly used ones are morpholine. Aluminum thioglycollate protects the gastric and esophageal mucosa, reduces damage to the mucosa from gastric acid, and acts as a physical barrier to adhere to the mucosal surface. In general, the treatment of esophagitis requires the selection of reasonable medication according to different conditions after a systematic and comprehensive examination by a clinician.