Tightness and pain in the middle of the chest may be related to lung diseases, heart diseases, digestive system diseases and so on. 1. Lung diseases: such as chronic obstructive pulmonary disease, bronchial asthma, lung tumors, etc., can appear coughing, wheezing, shortness of breath and other uncomfortable symptoms, but also appear to appear chest tightness and pain. 2. Heart disease: such as coronary heart disease, myocarditis, myocardial infarction and other diseases, will lead to chest tightness and pain symptoms. It is recommended to go to the hospital in time, can carry out electrocardiogram, X-ray examination, cardiac ultrasound and other examinations, to clarify the cause of the disease, and active treatment. 3. Digestive system diseases: For example, when reflux esophagitis occurs, in addition to the symptoms of heartburn and acid reflux, it will also lead to chest tightness and pain. At this time, it is recommended to go to the hospital to do gastroscopy and other related examinations, clear diagnosis and treatment. 4. Others: diseases such as costochondritis, intercostal neuralgia, pleurisy, etc., which lead to tightness and pain in the middle of the chest, it is recommended to go to the thoracic surgery for timely treatment. In addition to resting, it is recommended to go to the hospital as soon as possible to rule out other causes, so as to facilitate the treatment of the cause, so as not to delay the condition.