Lymph nodes are an important part of the human immune system, and are more frequently distributed in the right lower abdomen in the mesentery and intestinal wall. If you find more lymph nodes enlarged in the right lower abdomen, you should consider appendicitis, non-specific mesenteric lymphadenitis, intestinal tuberculosis, malignant tumors and other causes. 1. Appendicitis: there are a lot of lymphatic tissues distributed on the surface of appendix, if appendicitis, the inflammatory factor will be transmitted through the lymphatic vessels or blood, which will cause swelling, pain and compensatory hyperplasia of lymph nodes, and then there is a phenomenon of more lymph nodes in the right lower abdomen. 2. Non-specific mesenteric lymphadenitis: due to bacterial or viral infections in the digestive or respiratory tract, mesenteric lymph nodes develop inflammatory lesions, resulting in the phenomenon of multiple lymph nodes in the lower right abdomen. It is common in children with respiratory tract infections, and in adults with intestinal tract infections. 3. Intestinal tuberculosis: due to intestinal tissue invasion by Mycobacterium tuberculosis, causing chronic specific infection, lymph in the play of its immune function, prone to the phenomenon of more lymph nodes in the right lower abdomen. 4. Malignant tumors: when suffering from lymphoma, lymphoblastic leukemia, lymphatic metastasis of various malignant tumors in the body (such as intestinal cancer, liver cancer, gastric cancer, renal cancer, etc.), all of them may invade the right lower abdominal lymph nodes and lead to the enlargement of these lymph nodes. When multiple lymph nodes are found in the right lower abdomen, complete examination should be done to clarify the diagnosis and follow the doctor’s instructions for treatment.