Age-related Macular Degeneration (AMD), also known as “age-related macular degeneration”, is a disease that becomes more prevalent and more severe as we age. Age-related macular degeneration is a disease that can lead to loss of central vision, which is necessary for you to do some “direct vision activities”, and is a degenerative eye disease that severely affects vision without causing eye pain. The dramatic loss of central vision can affect reading, driving, time recognition and facial features, and eventually lead to blindness. Age-related macular degeneration starts from the degeneration of the cells in the macular region at the center of the retina, which can progress very slowly and is not obvious in the early stage. Many patients will develop severe lesions that seriously affect their vision. In some patients, the disease progresses more rapidly. Age-related macular degeneration usually develops in both eyes, but often in one eye earlier than the other. Age-related macular degeneration is one of the leading causes of severe vision loss in people aged 50 and older, and is one of the top diseases causing blindness in adults worldwide. According to a study by the World Health Organization, age-related macular degeneration accounts for about 8.7% of the world’s blind, and about 500,000 people go blind every year because of age-related macular degeneration. The results of a survey conducted by Zou Haidong and others in China showed that the prevalence of age-related macular degeneration in people over 50 years old was 15.5%. Among them, wet age-related macular degeneration accounts for 11.9%. According to the population data of the United Nations, the number of people over 50 years old in China was close to 300 million in 2005, according to this ratio, the total number of patients with age-related macular degeneration over 50 years old in China should be close to 40 million. In Singapore, a predominantly Chinese Asian country, age-related macular degeneration is also becoming a major cause of blindness, with a prevalence rate of 27% in people over 60 years old, and most of them have not been diagnosed in time. This shows that with the aging of the population, the prevalence of age-related macular degeneration will increase year by year, and the consequent public health problems cannot be ignored. Age-related macular degeneration is divided into two types: dry and wet. Dry age-related macular degeneration occurs when the photoreceptor cells in the macula of the affected eye are slowly destroyed and the central vision is gradually blurred. As dry age-related macular degeneration worsens, a blurred dark spot will appear in the center of your visual field, and as the macular function gradually decreases over time, the central vision of the affected eye will gradually be lost. The most common symptom of dry age-related macular degeneration is slight blurring of vision. You may have difficulty recognizing faces and need more light to read or do other things. Dry age-related macular degeneration usually involves both eyes, but there may be cases where vision is lost in one eye and the other eye does not seem to be involved. In wet AMD, also known as neovascular or exudative AMD, new abnormal blood vessels in the choroid proliferate and cross the retinal pigment epithelium. Since the new blood vessels are fragile and prone to rupture and bleeding or leakage of blood components, leading to retinal detachment, macular edema, and causing distortion of visual objects or formation of blind spots, and consequently significant loss of vision, wet age-related macular degeneration is a disease that seriously affects vision, daily life and activities. With the development of wet age-related macular degeneration, the central vision will be lost rapidly, and the patient can become blind within 2-3 months. Wet age-related macular degeneration can be said to be a kind of advanced age-related macular degeneration, and its severity is far more than that of dry age-related macular degeneration. Wet age-related macular degeneration mostly causes severe visual impairment, accounting for 90% of the severe visual impairment caused by age-related macular degeneration. The symptoms of wet AMD, such as vision loss, visual distortion and central dark spot, seriously affect the ability to perform daily tasks such as cooking, household chores, making phone calls and shopping. The rapid development of wet AMD and the high rate of blindness bring heavy mental and economic burdens to patients and society. Foreign studies show that the disease burden of wet AMD is greater than that of AIDS and cancer.