Diarrhea in advanced stage of liver cancer does not necessarily mean that the disease has deteriorated. Diarrhea is not necessarily a sign that the condition has further deteriorated, if it can be relieved in a short period of time, it is usually not a deterioration. Advanced liver cancer will affect the function of gastrointestinal tract, resulting in very weak digestion and absorption, and formation of cancerous thrombus in portal vein and inferior vena cava, leading to obstruction of blood reflux, which will cause recurrent diarrhea symptoms. Patients with advanced stage of liver cancer will have poor physique, which will easily lead to imbalance of gastrointestinal flora and thus diarrhea symptoms, probiotics and other drugs can be used to regulate intestinal function. Avoid eating hard food in daily life, so as not to aggravate the burden of gastrointestinal tract. Patients with advanced liver cancer with diarrhea should inform the doctor in time and deal with it under the doctor’s guidance.