Trimethoprim and budesonide are both glucocorticoid drugs, the two drugs can not be compared to which is better, should be based on the patient’s specific situation to choose the appropriate medication. Triamcinolone acetonide is a glucocorticoid drug with persistent anti-inflammatory and anti-allergic effects, which is mainly applied to various skin diseases, bronchial asthma, allergic rhinitis, arthralgia, periarthritis, tenosynovitis and other diseases. Trimethoprim can cause urticaria, bronchospasm, and common nasal sprays can also induce nosebleeds, pharyngitis, headache, drug rhinitis and other adverse reactions. Budesonide also belongs to the glucocorticoid class of drugs, but it is more suitable for patients with glucocorticoid-dependent or non-dependent bronchial asthma and asthmatic chronic bronchitis, and it has a better ameliorative effect on mild and moderate colonic Crohn’s disease and ulcerative colitis. Budesonide can induce certain allergic reactions and may present some psychiatric symptoms such as nervousness, restlessness and depression, as well as cause throat irritation, cough and other adverse reactions. The above drugs need to be standardized and rationally applied under the guidance of professional physicians and pharmacists. In addition, it should be noted that glucocorticoid drugs should not be used for a long time to prevent the induction of osteoporosis, infection, obesity and so on.