There are many causes of not being able to make a tight fist, such as rheumatoid arthritis, neurological disorders, tenosynovitis, nerve entrapment or injury, etc. Its treatment needs to be targeted according to the cause of the disease, including medication, closure therapy, physical therapy, surgical treatment and so on. 1. Rheumatoid arthritis: symptoms such as finger stiffness and inability to clench fists can be seen. Non-steroidal anti-inflammatory drugs such as indomethacin and nimesulide can be used, along with anti-rheumatic drugs such as methotrexate, etc. Glucocorticosteroids, such as prednisone, etc., can also be used if necessary. If the conservative treatment is not effective, surgery can be considered. 2. Neurological diseases: such as myasthenia gravis, the patient may have unexplained muscle atrophy, resulting in the hand can not hold a fist, generally can take cholinesterase inhibitors for treatment, such as brompheniramine. 3. Tenosynovitis: you can take the brake rest, with local hot compresses and other physiotherapy, oral non-steroidal anti-inflammatory drugs, such as ibuprofen, etc., but also local closed treatment, local injection of hormones and anesthesia drugs. If the symptoms are serious, surgery may need to be considered. 4. Nerve compression or injury: when trauma or local inflammation causes ulnar nerve or median nerve compression or injury, the affected limb should be rested and elevated in a timely manner, and can be combined with methylcobalamin and other nutritive nerve medications, and if necessary, surgical treatment is required. If you can’t make a tight fist, it is recommended that you go to the hospital in time for regular treatment.