Liver metastasis of colon cancer also needs active treatment to improve patients’ quality of life and prolong their survival. Colon cancer refers to malignant tumors that occur in the colon and can metastasize to the liver. Colorectal combined liver metastasis is already in advanced stage, and combined liver metastasis is mainly treated by surgery, intervention, radiotherapy, targeted therapy and immunotherapy. As follows: 1. If the primary focus and liver metastasis can be resected, the two can be resected together; 2. If the primary foci can be resected but the metastases cannot be resected, palliative resection can be performed on the primary foci, and the metastases can be treated with interventional therapy (e.g., transvascular chemoembolization, radiofrequency ablation, injection of anhydrous alcohol, etc.) or local radiotherapy; 3. If the primary foci cannot be removed, “short-circuit” surgery or stoma surgery is feasible. In addition, after surgical treatment, patients need to choose chemotherapy, radiotherapy, targeted therapy, immunotherapy, etc. according to the situation. In conclusion, colorectal combined liver metastasis is advanced and requires comprehensive treatment. It is recommended to go to the regular hospital for comprehensive assessment of the condition, choose the appropriate treatment plan according to the situation, and follow the doctor’s instructions to actively cooperate with the treatment, so as to avoid delaying the condition.