It is possible for the tumor to shrink after chemotherapy for squamous lung cancer. After diagnosis of squamous lung cancer, it can be treated by surgical resection, radiotherapy or chemotherapy under doctor’s guidance. It is possible for the tumor to shrink after chemotherapy, which indicates that the current chemotherapy regimen is effective; for some early-stage squamous lung cancer patients whose tumor shrinks after chemotherapy and then undergo radical surgical resection, the possibility of postoperative cure will be greatly enhanced. However, if the patient is not sensitive to chemotherapy drugs, then the tumor may not shrink or even develop further. Patients diagnosed with squamous lung cancer should actively cooperate with doctors in treatment, maintain a healthy lifestyle and a good mindset, all of which can help improve the prognosis.