After the appearance of acne during breastfeeding, the patient’s symptoms can be improved through the topical application of benzoyl peroxide, antibiotic ointment and retinoic acid cream. 1. benzoyl peroxide: benzoyl peroxide medication applied topically can slowly release new ecological oxygen and benzoic acid, can play a role in killing Propionibacterium acnes and dissolve acne and astringent, can be used as one of the first choice of topical antimicrobial drugs for inflammatory acne. 2. Antibiotic creams: such as clindamycin, erythromycin, fusidic acid cream, etc., all belong to antibiotic creams, but because topical antibiotics can easily lead to drug resistance of Propionibacterium acnes, so it is not recommended to use them alone, but can be applied in combination with the above drugs. 3. Vitamin A cream: Small topical application of vitamin A cream can be used for the treatment of mild to moderate acne, which can regulate the cellular differentiation of the epidermal keratin formation and also dissolve microcomedones. It is recommended that patients with breastfeeding acne phenomenon, should be combined with their own situation, with the doctor’s medication, must not blindly use drugs, so as not to produce adverse effects.