A blockage in a heart vessel, i.e., a 100% narrowing of a coronary artery, requires rapid opening of the blocked coronary artery and can be treated with interventional therapy or, if not available, pharmacological thrombolysis. How long a person can live with a blocked heart vessel depends on the location of the blockage and the speed of the blockage, but the life expectancy of the patient is very much influenced by many factors and cannot be generalized. It is very well understood that the site of coronary artery occlusion is important, as acute mortality is high in the case of acute occlusion of the left main or anterior descending branch and the proximal segment of the right coronary and ileal branches; the speed of occlusion is also important, as sudden acute thrombosis to 100% occlusion from a mild to moderate stenotic lesion can also greatly increase mortality. Therefore, the site of coronary occlusion and whether it is acute are key factors affecting survival. However, a growing number of studies have shown that a significant proportion of patients lack clinical symptoms, are generally well, and even lack laboratory and imaging evidence of myocardial ischemia despite significant stenosis or even 100% occlusion of the coronary arteries. Some researchers have suggested that the anatomical stenosis of coronary arteries has its limitations, and the impact of coronary flow function and coronary microcirculation on clinical prognosis should be more fully evaluated. Therefore, we cannot generalize about the life expectancy of a person who is found to have severe stenosis or even blockage of coronary arteries, because what we can determine as “coronary artery blockage” is only the tip of the iceberg that affects the risk of cardiovascular death, and a comprehensive analysis is needed. Therefore, the prognosis of patients with coronary artery disease varies greatly, with 550,000 sudden deaths in China each year, 80% of which are related to cardiovascular pathology; while some people can even survive for a long time without symptoms, only to be found to have had a heart attack when they have an EKG or cardiac ultrasound. The future cannot be fully predicted, but regular medical checkups and risk factor prevention and control must be within our reach and beneficial.