It is impossible to generalize how many times hepatitis B immunoglobulin should be given. When adults use it for prevention of accidental exposure or prevention of hepatitis B, it is usually given once, and can be given again at intervals if necessary; when children use it for prevention of hepatitis B, it can be given once or twice, and newborn babies need to be injected several times when they use it for interruption of mother-to-child transmission. 1. Adults: When adults use hepatitis B immunoglobulin for post-accidental exposure, it needs to be given once within 24 hours after exposure and according to the procedure of hepatitis B vaccination, and it can be given again at intervals of 3-4 weeks if necessary; if used for the prevention of hepatitis B, it is usually given once, and it can also be given again at intervals of 3-4 weeks if necessary. 2. Children: If children use hepatitis B immunoglobulin to prevent hepatitis B, it is usually given once, and if necessary, it can be given at intervals of 3~4 weeks; if it is used to help newborns to prevent mother-to-child transmission, hepatitis B immunoglobulin alone needs to be given several times, and it is given once every 3~4 weeks. Hepatitis B Immunoglobulin injections may cause localized pain and, in rare cases, angioedema and urticaria. Individuals should use Hepatitis B Immunoglobulin properly under the supervision of a physician and inform the physician of any unusual discomfort after administration.