Prolapse, or rectal prolapse, refers to a condition in which the rectum of the anal canal prolapses outside the anus due to exenteration. Gastrointestinal dilatation with prolapse is seen in some patients with elastic pseudoxanthomatosis. The dilatation is caused by gas accumulation in the stomach and intestines due to abnormal digestive function. Pseudoxanthomatosis elastica is a systemic elastic fiber disorder, the cause of which is unknown to date. It predominantly affects young women. There are mainly skin lesions, cardiovascular lesions, gastrointestinal lesions, ocular lesions, neuropsychiatric lesions, and renal lesions. The disease is diagnosed on the basis of the presence of a yellowish to orange rash on areas of the skin that are subjected to more friction and the presence of thickened, less elastic and flaccid skin with characteristic vascular-like lines in the fundus and signs and symptoms of embolism in the internal organs. It should be distinguished from sclerosing atrophic mossy scleroderma and cutaneous flaccidities. All of these diseases do not have skin, fundus and vascular manifestations that coexist with this disease. There is no specific treatment for this disease, and symptomatic treatment is mostly used. For skin lesions, local injection of 1% procaine is used, which can sometimes stop the deterioration of the lesions. For excessively extensive skin folds, orthopedic surgery is feasible. For those with gastrointestinal bleeding, blood transfusion and hemostatic drugs should be given. For those with hypertension or coronary artery supply insufficiency, vasodilatation, anticoagulation and administration of thrombolytic agents, such as urokinase, are required, and once heart failure and cerebrovascular accidents occur, they should be treated accordingly. It has been reported that the application of vitaminase and vitamin E is effective in relieving skin lesions and eye symptoms, while other drugs such as salicylic acid preparations and antihistamines are not yet effective.