The common causes of low urine volume and body fatigue in 44-year-old women are glomerulonephritis, renal failure, etc. It may also be caused by physiological reasons, and you should consult a doctor in time to find out the cause of the disease. 1. Physiological reasons: may be the usual amount of water is too little, the body sweats too much, so that the body does not have enough water caused by adequate rest and drink more water symptoms can be relieved. 2. Glomerulonephritis: if glomerulonephritis is accompanied by severe edema, the water in the blood vessels goes into the subcutaneous, the volume of the blood vessels will be reduced, which will be manifested as urinary insufficiency; if glomerulonephritis is accompanied by the elevation of creatinine, the function of the kidneys in excreting the water will be affected, even if there is sufficient water in the blood vessels of the body, the water can not be excreted through the kidneys, and the situation of urinary insufficiency will occur as well. 3. Renal failure: it is mainly due to the ischemia and necrosis of renal tubules caused by toxin substances, so that the glomerular filtration function is impaired, thus reducing the amount of urine formed by the kidneys and causing urinary insufficiency. If there is a combination of symptoms of urinary tract obstruction, it will cause the urine can not be discharged out of the body in time, which will be manifested as low urine. In case of low urine output and body fatigue, it is necessary to consult a doctor in time to find out the cause of the disease, so as not to delay the condition.