Stage IV lung adenocarcinoma is in the advanced stage of cancer, and the five-year survival rate is around 20% if it is treated in an active and standardized way. When lung adenocarcinoma is in stage IV, the differentiation of tumor cells becomes low, the degree of malignancy of cancer cells is high, and the lesions have already metastasized to all parts of the body, at this time, most of the patients may not be able to undergo surgical treatment. However, if the patient has mutations in sensitive genes, he/she can choose targeted treatment with specific drugs, and if the body is more receptive, the five-year survival rate of the patient can be up to 20% with other treatments. If patients with stage IV lung adenocarcinoma have poor physical foundation and extensive metastasis, and their tolerance to targeted drugs is not good, they should also actively cooperate with doctors to carry out local or systemic chemotherapy, radiotherapy and other comprehensive treatments, which can also prolong the survival period of patients to a certain extent. The most important thing for patients with stage IV lung adenocarcinoma is to keep a positive and optimistic mindset, actively cooperate with doctor’s treatment measures, eat more protein-rich food to supplement nutrition, and try to prolong their survival period.