The most commonly used clinical drug for cirrhosis and lowering portal pressure is propranolol hydrochloride, which is often referred to as “Propranolol”. Its main mechanism of action is to control the heart rate and reduce the blood flow to the internal organs, which can reduce portal hypertension. If the heart rate drops significantly to below 60 beats per minute it is recommended to stop using propranolol, other specific usage, dosage, and how to adjust the dose should be used under the guidance of a doctor. In addition, there are diuretics spironolactone and furosemide, which will reduce ascites and also reduce portal hypertension.