Children with persistent fever of 39 degrees can not come down may be associated with infectious factors or non-infectious factors, in the antipyretic treatment at the same time, need to pay attention to the treatment of the original disease. When the body temperature ≥ 38.5 ℃ need to use antipyretic drugs such as ibuprofen, acetaminophen and other antipyretic treatment under the guidance of the doctor. At the same time, we need to actively use warm water on the child’s forehead, reduce the clothing worn and other physical methods to lower the temperature. At the same time, the treatment of the cause of the disease is also very important for the recovery of body temperature, such as respiratory tract infections caused by bacterial infections, need to actively use antibacterial drugs such as cefaclor, cefdinir and other anti-infective treatment. In case of juvenile idiopathic arthritis and other rheumatic immune diseases, methotrexate, hydroxychloroquine and other drugs should be used for treatment. All of the above medications should be used under doctor’s supervision, avoid self-medication. Children with persistent fever are advised to seek prompt medical attention and be evaluated for treatment by a specialist.